- P-ISSN 2233-4203
- E-ISSN 2093-8950
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- P-ISSN2233-4203
- E-ISSN2093-8950
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Simple and Rapid Liquid Chromatography-Tandem Mass Spectrometry Analysis of Arctigenin and its Application to a Pharmacokinetic Study
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2017, v.8 no.2, pp.23-28
https://doi.org/10.5478/MSL.2017.8.2.23
(Wonkwang University)
(Catholic University of Daegu)
(Catholic University of Daegu)
(University of Florida)
(Wonkwang University)
(Wonkwang University)
(Chonbuk National University)
(Wonkwang University)
(Sungkyunkwan University)
(Sungkyunkwan University)
(Wonkwang University)
(Catholic University of Daegu)
(Catholic University of Daegu)
(University of Florida)
(Wonkwang University)
(Wonkwang University)
(Chonbuk National University)
(Wonkwang University)
(Sungkyunkwan University)
(Sungkyunkwan University)
(Wonkwang University)
Thapa,
S. K., Weon,
K., Jeong,
S. W., Kim,
T. H., Upadhyay,
M., Han,
Y., Jin,
J., Hong,
S., Youn,
Y. S., Shin,
B. S., &
Shin,
S.
(2017). Simple and Rapid Liquid Chromatography-Tandem Mass Spectrometry Analysis of Arctigenin and its Application to a Pharmacokinetic Study. Mass Spectrometry Letters, 8(2), 23-28, https://doi.org/10.5478/MSL.2017.8.2.23
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Abstract
Arctigenin is the main active ingredient of Fructus Arctii, which has been reported with a variety of therapeutic activities including anti-cancer, anti-inflammation, anti-virus, and anti-obesity effects. In this study, a simple and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of arctigenin in rat plasma. The assay utilized a simple protein precipitation with methanol and the mobile phase consisted of 100% methanol and water containing 0.1% formic acid (65:35 v/v). Arctigenin and the internal standard (psoralen) were monitored using a positive electrospray turbo ionspray mode with multiple reaction monitoring transitions of m/z 373.2→136.9 and m/z 187.2→130.9, respectively, and total chromatographic run time was within 5 min. The lower limit of quantification (LLOQ) of arctigenin was 5 ng/mL in the rat plasma. The intra- and inter-day accuracy of arctigenin at LLOQ and matrix-matched quality control samples ranged 97.4 – 104.8% and 97.2 – 102.0%, respectively. The intra-day precision was within 4.80% and the interday precision was within 5.92%. Application of the present method was demonstrated through a pharmacokinetic study after intravenous and oral administration of arctigenin in male Sprague Dawley rats.
- keywords
- Fructus Arctii, Arctigenin, LC-MS/MS, pharmacokinetics
Reference
1
Sun, W. (1992). . Yao Xue Xue Bao, 27, 549-.
2
Nose, M. (1993). . Planta Med, 59, 131-.
3
Hoon, H. B. (1994). . Phytochemistry, 37, 1161-.
4
Hirose, M. (2002). . Environ. Mol. Mutagen, 39, 271-.
5
Susanti, S. (2012). . J. Nat. Med, 66, 614-.
6
Liu, H. (2010). . J. Chromatogr. B, 878, 2707-.
7
Gu, Y. (2012). . Biochem. Pharmacol, 84, 468-.
8
Takasaki, M. (2000). . Cancer Lett, 158, 53-.
9
Strimpakos, A. S. (2013). . JOP, 14, 354-.
10
Wang, P. (2015). . Mol. Nutr. Food Res, 59, 250-.
11
Kim, A.-R. (2012). . Eur. J. Pharmacol, 682, 29-.
12
Huang, S.-L. (2012). . Diabetologia, 55, 1469-.
13
Fan, T. (2012). . Biol. Pharm. Bull, 35, 2004-.
14
Zhao, F. (2009). . J. Ethnopharmacol, 122, 457-.
15
Hayashi, K. (2010). . Biol. Pharm. Bull, 33, 1199-.
16
Li, D. (2014). . Planta Med, 80, 48-.
17
Liu, H. (2015). . Pharm. Biol, 1, -.
18
Han, Y. H. (2016). . J. Cell. Biochem, , -.
19
Gao, Q. (2014). . J. Pharm. Biomed. Anal, 91, 60-.
20
Heinonen, S. (2001). . J. Agric. Food Chem, 49, 3178-.
21
Zhao, Y. (2009). . Chin. J. Chem, 67, 1123-.
22
Kasper, R. (1994). . Planta Med, 60, 441-.
23
Gao, Q. (2013). . Planta Med, 79, 471-.
24
Xu, Z. (2015). . Phytomedicine, 22, 128-.
25
Liu, S. (2005). . Phytochem. Anal, 16, 86-.
26
Boldizsár, I. (2010). . J. Chromatogr. A, 1217, 1674-.
27
He, F. (2013). . Nat. Prod. Res, 27, 903-.
28
He, F. (2012). . Planta Med, 78, 800-.
29
Zou, Q. (2013). . Biomed. Chromatogr, 27, 1123-.
30
Zeng, X.-y. (2015). . Fitoterapia, 105, 119-.
31
Gao, Q. (2014). . The AAPS journal, 16, 1321-.
- Submission Date
- 2017-06-01
- Revised Date
- 2017-06-13
- Accepted Date
- 2017-06-13
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