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- E-ISSN 2093-8950
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- E-ISSN2093-8950
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Phospholipid Analysis by Nanoflow Liquid Chromatography-Tandem Mass Spectrometry
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2014, v.5 no.1, pp.1-11
https://doi.org/10.5478/MSL.2014.5.1.1
(Yonsei University)
Moon,
M.
H.
(2014). . Mass Spectrometry Letters, 5(1), 1-11, https://doi.org/10.5478/MSL.2014.5.1.1
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Abstract
Lipids play important roles in biological systems; they store energy, play a structural role in the cell membrane, and areinvolved in cell growth, signal transduction, and apoptosis. Phospholipids (PLs) in particular have received attention in the medical andlipidomics research fields because of their involvement in human diseases such as diabetes, obesity, atherosclerosis, and many cancersassociated with lipid metabolic disorders. Here I review experimental strategies for PL analysis based on nanoflow liquid chromatography-electrospray ionization-tandem mass spectrometry (nLC-ESI-MSn). In particular, discussed are lipid extraction methods, nanoflowLC separation of PLs, effect of ionization modifiers on the ESI of PLs, influence of chain lengths and unsaturation degree of acyl chainsof PLs on MS intensity, structural determination of the molecular structure of PLs and their oxidized products, and quantitative profilingof PLs from biological samples such as tissue, urine, and plasma in relation to cancer and coronary artery disease.
- keywords
- lipid, phospholipid, nLC-ESI-MS/MS, lipidomics, oxidized PLs
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- 투고일Submission Date
- 2014-02-05
- 수정일Revised Date
- 2014-02-25
- 게재확정일Accepted Date
- 2014-02-25
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