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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

General Fragmentations of Alkaloids in Electrospray Ionization Tandem Mass Spectrometry

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2013, v.4 no.4, pp.79-82
https://doi.org/10.5478/MSL.2013.4.4.79
Shim Hee Jung (Kyung Hee University)
Lee Ji Ye (Kyung Hee University)
Kim Byungjoo (Korea Research Institute of Standard and Science)
Hong Jongki (Kyung Hee University)
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Abstract

Various types of alkaloids observed in several herbal medicines were analyzed by electrospray ionization tandemmass spectrometry in positive ion mode. In the present study, MS/MS spectralpatterns were investigated for eight-types of alkaloids(aporpine, protoberberine, tetrahydroprotoberberine, benzylisoquinoline, protopine, phthalide, morpine, and bisbenzylisoquinoline). For aporpine- and protoberberine-type alkaloids, main fragmentations occurred at substituted groups on rigid ringstructures, not showing ring fusion. Interesting fragmentations due to iminolization and retro-Diels-Alder (RDA) reaction wereobserved in MS/MS spectra of protopine- and tetrahydroprotobereberine-type alkaloids. Also, several types of fragmentationssuch as inductive cleavage and α-cleavage, or bond cleavage between two ring structures were observed depending on theirstructural characteristics. These fragmentation patterns are expected to allow instant classification of the specific alkaloid type invarious MS/MS spectra of alkaloids.

keywords
Alkaloids, General fragmentation, MS/MS spectral patterns, Tandem mass spectrometry


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Submission Date
2013-12-09
Revised Date
2013-12-17
Accepted Date
2013-12-17
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