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- E-ISSN 2093-8950
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- E-ISSN2093-8950
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Effects of Mollugin on Hepatic Cytochrome P450 in Male ICR Mice as Determined by Liquid Chromatography/Tandem Mass Spectrometry
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2012, v.3 no.4, pp.104-107
https://doi.org/10.5478/MSL.2012.3.4.104
(Kyungpook National University)
(Kyungpook National University)
(Yeungnam University)
(Yeungnam University)
(Yeungnam University)
(Kyungpook National University)
(Kyungpook National University)
(Yeungnam University)
(Yeungnam University)
(Yeungnam University)
(Kyungpook National University)
Song,
M., Hong,
M., Choi,
H. G., Jahng,
Y., Lee,
S. H., &
Lee,
S.
(2012). Effects of Mollugin on Hepatic Cytochrome P450 in Male ICR Mice as Determined by Liquid Chromatography/Tandem Mass Spectrometry. Mass Spectrometry Letters, 3(4), 104-107, https://doi.org/10.5478/MSL.2012.3.4.104
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Abstract
Mollugin isolated from Rubia cordifolia is known to have anti-inflammatory, anti-cancer, and anti-viral activities. Inthe present study, a cocktail probe assay and LC-MS/MS were used to investigate the modulating effect of mollugin on cytochromeP450 (CYP) enzymes in male ICR mice. After mollugin was orally administrated to mice at the 20, 40, or 80 mg/kg for3 days, the activities of CYP in hepatic S-9 fractions were investigated. Unlike the selective inhibitory effect of mollugin onCYP1A2-catalyzed phenacetin O-deethylation in vitro, mollugin only significantly inhibited the activity of CYP2E1-catalyzedchlorzoxazone 6-hydroxylase in vivo. The activities of other CYPs were only slightly altered by mollugin. The results of thisstudy suggest that mollugin might cause herb-drug interactions via the selective inhibition of CYP2E1 in vivo.
- keywords
- Mollugin, Cytochrome P450, ICR mice, Induction, LC-MS/MS
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- Submission Date
- 2012-11-28
- Revised Date
- 2012-12-14
- Accepted Date
- 2012-12-16
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