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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

Identification of Ceftiofur Oxidation Products by High-Performance Liquid Chromatography/Electrospray Ionization/Tandem Mass Spectrometry

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2011, v.2 no.1, pp.16-19
https://doi.org/10.5478/MSL.2011.2.1.016
Lim Young-Hee (LG Chem)
Park Deok-Hie (LG Chem)
Youn Yeu Young (LG Chem)
Kim Kyung Hoon (LG Chem)
Cho Hye-Sung (LG Chem)
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Abstract

Oxidation products of ceftiofur were formed in hydrogen peroxide solution. The structures of the ceftiofur oxidationproducts were characterized by high-performance liquid chromatography/electrospray ionization/tandem mass spectrometry(HPLC/ESI/MS/MS). The products were identified as compounds oxidized at the sulfur of a cephem ring. For further analysis,an experiment was performed using O18-labeled hydrogen peroxide. Results of the density-functional calculations for six possibleoxidation products were in good agreement with the experimental results.

keywords
Ceftiofur, Oxidation, ESI, Density-functional Calculation, Hydrogen Bonding


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Submission Date
2011-02-03
Revised Date
2011-03-07
Accepted Date
2011-03-07
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