- P-ISSN 2233-4203
- E-ISSN 2093-8950
- 권한신청
- P-ISSN2233-4203
- E-ISSN2093-8950
논문 상세
Home > 논문 상세
Inhibitory Effects of Dietary Schisandra Supplements on CYP3A Activity in Human Liver Microsomes
Inhibitory Effects of Dietary Schisandra Supplements on CYP3A Activity in Human Liver Microsomes
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2022, v.13 no.4, pp.152-157
https://doi.org/10.5478/MSL.2022.13.4.152
(Kyungpook National University)
(Kyungpook National University)
(Kyungpook National University)
(Kyungpook National University)
(Kyungpook National University)
(Kyungpook National University)
(Kyungpook National University)
Kang,
B.,
Park,
E.,
Park,
S.,
&
Liu,
K.
(2022). Inhibitory Effects of Dietary Schisandra Supplements on CYP3A Activity in Human Liver Microsomes. Mass Spectrometry Letters, 13(4), 152-157, https://doi.org/10.5478/MSL.2022.13.4.152
- 다운로드 수
- 조회수
초록
Schisandra chinensis and its fruits have been used as a traditional herbal medicine to treat liver dysfunction, fatigue, and chronic coughs. Several in vitro and in vivo studies suggested that dibenzocyclooctadiene lignans present in Schisandra fruits strongly inhibit CYP3A4 activity. However, reports on the inhibitory potential of dietary Schisandra supplements against CYP3A activity are limited despite their increasing consumption as dietary supplements. In this study, we evaluated the CYP3A- inhibitory potential of four dietary Schisandra supplements in human liver microsomes. At a concentration of 0.05 mg/mL, Schisandra supplements from Nature’s Way, Swanson, Planetary Herbals, and Only Natural inhibited CYP3A activity by 93.9, 70.8, 33.6, and 24.8%, respectively. Nature’s Way, which exhibited the strongest inhibition against CYP3A, had the highest con- tents of gomisin B and gomisin C, which potently inhibit CYP3A activity. The in vivo pharmacokinetics of this product should be examined to determine whether the clinical relevance of inhibiting CYP3A activity by dietary Schisandra supplementation.
- keywords
- CYP3A, Inhibition, Lignan, Schisandra supplements
Abstract
Schisandra chinensis and its fruits have been used as a traditional herbal medicine to treat liver dysfunction, fatigue, and chronic coughs. Several in vitro and in vivo studies suggested that dibenzocyclooctadiene lignans present in Schisandra fruits strongly inhibit CYP3A4 activity. However, reports on the inhibitory potential of dietary Schisandra supplements against CYP3A activity are limited despite their increasing consumption as dietary supplements. In this study, we evaluated the CYP3A- inhibitory potential of four dietary Schisandra supplements in human liver microsomes. At a concentration of 0.05 mg/mL, Schisandra supplements from Nature’s Way, Swanson, Planetary Herbals, and Only Natural inhibited CYP3A activity by 93.9, 70.8, 33.6, and 24.8%, respectively. Nature’s Way, which exhibited the strongest inhibition against CYP3A, had the highest con- tents of gomisin B and gomisin C, which potently inhibit CYP3A activity. The in vivo pharmacokinetics of this product should be examined to determine whether the clinical relevance of inhibiting CYP3A activity by dietary Schisandra supplementation.
- keywords
- CYP3A, Inhibition, Lignan, Schisandra supplements
- 투고일Submission Date
- 2022-11-09
- 수정일Revised Date
- 2022-12-13
- 게재확정일Accepted Date
- 2022-12-21
권호 내 다른 논문
- Mass Spectrometry-Based Analytical Methods of Amatoxins in Biological Fluids to Monitor Amatoxin-Induced Mushroom Poisoning
- High-Throughput Screening Technique for Microbiome using MALDI-TOF Mass Spectrometry: A Review
- Combining the Power of Advanced Proteome-wide Sample Preparation Methods and Mass Spectrometry for defining the RNA-Protein Interactions
- Headspace GC-MS Analysis of Spring Blossom Fragrance at Chungnam National University Daedeok Campus
- The Advanced Analytical Method Through the Quantitative Comparative Study of Taurine in Feed Using LC-MS/MS
- Relative Quantification of Glycans by Metabolic Isotope Labeling with Isotope Glucose in Aspergillus niger
- A Sensitive, Efficient, and Cost-Effective Method to Determine Rotigotine in Rat Plasma Using Liquid-Liquid Extraction (LLE) and LC-MRM
- Inhibitory Effects of Dietary Schisandra Supplements on CYP3A Activity in Human Liver Microsomes
- Simultaneous Liquid Chromatography Tandem Mass Spectrometric Determination of 35 Prohibited Substances in Equine Plasma for Doping Control
- Comparative Analysis of the Phyto-compounds Present in the Control and Experimental Peels of Musa paradisiaca used for the Remediation of Chromium Contaminated Water
- Analysis of Amyloid Beta 1-16 (Aβ16) Monomer and Dimer Using Electrospray Ionization Mass Spectrometry with Collision-Induced Dissociation
- Comparative Sample Preparation Methods for a Label-Free Proteomic Analysis
- more
추천 논문
학술지 홈페이지 이용 환경은 크롬 브라우저 사용을 권장합니다.