• P-ISSN2233-4203
  • E-ISSN2093-8950

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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

Mass Spectrometry-based Hair Metabolomics for Biomarker Discovery

Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2022, v.13 no.1, pp.2-10
https://doi.org/10.5478/MSL.2022.13.1.2
Lee Yu Ra (Korea Institute of Science and Technology)
Hong Jongki (Kyung Hee University)
Chung Bong Chul (Korea Institute of Science and Technology)

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Abstract

Metabolomics makes it possible to analyze the interrelationships between various signaling molecules based on the metabolic pathways involved by using high-resolution devices. This approach can also be used to obtain large-scale metabolic information to identify the relevant pathways for disease diagnosis and prognosis and search for potential biomarkers. In the fields of medicine and forensics, hair analysis is used to detect various metabolites in the body. Hair can be harvested readily in a noninvasive manner and is easier to transport and store than blood and urine. Another advantage from a forensic viewpoint is that hair reflects all the components of body fluids. In addition, because of the unique coating structure of hair, it can be used for measurements without changing or destroying its adsorbed components. In this review, the pretreatments for hair analysis, instrumental conditions and clinical applications are discussed. Especially, the clinical use of hair metabolomics in the diagnosis of various diseases and the limitations of the technique are described.

keywords
hair metabolomics biomarker steroids


Submission Date
2022-01-10
Revised Date
2022-02-28
Accepted Date
2022-03-02
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Mass Spectrometry Letters