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  • P-ISSN2233-4203
  • E-ISSN2093-8950

Serum Proteomic Analysis of Scrub Typhus Patients for Screening Antigenic Proteins Originating from Orientia tsutsugamushi

Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2021, v.12 no.3, pp.76-80
https://doi.org/10.5478/MSL.2021.12.3.76
Sang-Yeop Lee (Korea Basic Science Institute)
Sung Ho Yun (Korea Basic Science Institute)
Geul Bang (Korea Basic Science Institute)
Chang-Seop Lee (Chonbuk National University Medical School)
Seung Il Kim (Korea Basic Science Institute)

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Abstract

Scrub typhus is an acute febrile disease caused by the pathogenic bacterium Orientia tsutsugamushi, belonging to the Rickettsiaceae family. The shotgun proteomic analysis was performed using the sera of scrub typhus patients to identify the pro-teins having their origin in O. tsutsugamushi. Three different databases approaches were used for the identification of the pro-teomes. We identified the RsmD, an RNA methyltransferase as the commonly detected protein from all three approaches. This protein was not detected in the sera of healthy negative controls. We believe that this protein is a potential biomarker of Orientia tsutsugamushi present in the sera of scrub typhus patients.

Submission Date
2021-08-02
Revised Date
2021-08-23
Accepted Date
2021-08-31

Mass Spectrometry Letters