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- E-ISSN 2093-8950
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Serum Proteomic Analysis of Scrub Typhus Patients for Screening Antigenic Proteins Originating from Orientia tsutsugamushi
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2021, v.12 no.3, pp.76-80
https://doi.org/10.5478/MSL.2021.12.3.76
(Korea Basic Science Institute)
(Korea Basic Science Institute)
(Korea Basic Science Institute)
(Chonbuk National University Medical School)
(Korea Basic Science Institute)
(Korea Basic Science Institute)
(Korea Basic Science Institute)
(Chonbuk National University Medical School)
(Korea Basic Science Institute)
Lee,
S., Yun,
S. H., Bang,
G., Lee,
C., &
Kim,
S.
I.
(2021). Serum Proteomic Analysis of Scrub Typhus Patients for Screening Antigenic Proteins Originating from Orientia tsutsugamushi. Mass Spectrometry Letters, 12(3), 76-80, https://doi.org/10.5478/MSL.2021.12.3.76
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Abstract
Scrub typhus is an acute febrile disease caused by the pathogenic bacterium Orientia tsutsugamushi, belonging to the Rickettsiaceae family. The shotgun proteomic analysis was performed using the sera of scrub typhus patients to identify the pro-teins having their origin in O. tsutsugamushi. Three different databases approaches were used for the identification of the pro-teomes. We identified the RsmD, an RNA methyltransferase as the commonly detected protein from all three approaches. This protein was not detected in the sera of healthy negative controls. We believe that this protein is a potential biomarker of Orientia tsutsugamushi present in the sera of scrub typhus patients.
- keywords
- Scrub typhus, Orientia tsutsugamushi, proteomic analysis, serum
- Submission Date
- 2021-08-02
- Revised Date
- 2021-08-23
- Accepted Date
- 2021-08-31
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