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  • P-ISSN2233-4203
  • E-ISSN2093-8950

Chromosome-Centric Human Proteome Study of Chromosome 11 Team

Chromosome-Centric Human Proteome Study of Chromosome 11 Team

, (P)2233-4203; (E)2093-8950
2021, v.12 no.3, pp.60-65
https://doi.org/10.5478/MSL.2021.12.3.60
(Korea Basic Science Institute)
(Korea Basic Science Institute)
(Korea Basic Science Institute)

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Abstract

As a part of the Chromosome-centric Human Proteome Project (C-HPP), we have developed a few algorithms for accurate identification of missing proteins, alternative splicing variants, single amino acid variants, and characterization of func-tion unannotated proteins. We have found missing proteins, novel and known ASVs, and SAAVs using LC-MS/MS data from human brain and olfactory epithelial tissue, where we validated their existence using synthetic peptides. According to the neXtProt database, the number of missing proteins in chromosome 11 shows a decreasing pattern. The development of genomic and transcriptomic sequencing techniques make the number of protein variants in chromosome 11 tremendously increase. We developed a web solution named as SAAvpedia for identification and function annotation of SAAVs, and the SAAV information is automatically transformed into the neXtProt web page using REST API service. For the 73 uPE1 in hromosome 11, we have studied the function annotaion of CCDC90B (NX_Q9GZT6), SMAP (NX_O00193), and C11orf52 (NX_Q96A22).

투고일Submission Date
2021-08-10
수정일Revised Date
2021-08-10
게재확정일Accepted Date
2021-08-19