- P-ISSN 2233-4203
- E-ISSN 2093-8950
- Apply for Authority
- P-ISSN2233-4203
- E-ISSN2093-8950
Article Detail
Home > Article Detail
Oligomer Complexes of the (VQIVYK + NNQQNY) and (VQIVYK + LYQLEN) Mixing Solutions
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2019, v.10 no.1, pp.32-37
https://doi.org/10.5478/MSL.2019.10.1.32
(Department of Applied Chemistry, Kumoh National In)
(Department of Applied Chemistry, Kumoh National Institute of Technology)
(Department of Applied Chemistry, Kumoh National Institute of Technology)
(Department of Applied Chemistry, Kumoh National Institute of Technology)
(Department of Applied Chemistry, Kumoh National Institute of Technology)
Jung,
Y., Shin,
M., &
Kim,
H.
(2019). Oligomer Complexes of the (VQIVYK + NNQQNY) and (VQIVYK + LYQLEN) Mixing Solutions. Mass Spectrometry Letters, 10(1), 32-37, https://doi.org/10.5478/MSL.2019.10.1.32
- Downloaded
- Viewed
Abstract
The π-π interactions of the peptide-dimer and peptide-trimer complexes were investigated in the (VQIVYK + LYQLEN) and (VQIVYK + NNQQNY) mixing solutions. The results showed that tyrosine (Y) residues were critical in the for-mation of hetero peptide-dimers and -trimers during the early oligomerization process. We used collision-induced dissociation (CID) along with electrospray ionization mass spectroscopy (ESI-MS) to obtain the structural information of the hetero-dimers and -trimers. We chose three amyloidogenic peptides–VQIVYK, NNQQNY, and LYQLEN–from tau protein, yeast prion-like protein Sup35, and insulin chain A, respectively. Hetero-dimer, -trimer, -tetramer, and -pentamer complexes were observed in the mass spectra. The tandem mass spectrum of the hetero-dimer and hetero-trimer showed two different fragmentation patterns (covalent and non-covalent bond dissociation). Y-Y interaction structures were also proposed for the hetero-dimer and -trimer complexes.
- keywords
- Peptide oligomer, VQIVYK, NNQQNY, LYQLEN, mass spectrometry (MS), MS/MS
Reference
1
Haass, C.. (2007). . J. Nat. Rev. Mol. Cell Biol, 8, 101-.
2
Eisenberg, D.. (2006). . Acc. Chem. Res, 39, 568-.
3
Sawaya, M. R.. (2007). . Nature, 447, 453-.
4
Nelson, R. (2005). . Nature, 435, 773-.
5
Cohen, A. S. (1959). . Nature, 183, 1202-.
6
Diaz-Avalos, R. (2003). . J. Mol. Biol, 330, 1165-.
7
Balbirnie, M. (2001). . Proc. Natl. Acad. Sci, 98, 2375-.
8
Plumley, J. A. (2010). . J. Am. Chem. Soc, 132, 1758-.
9
Lin, Y.-F. (2009). . Biopolymers, 94, 269-.
10
Vaden, T. D. (2008). . J. Am. Chem. Soc, 130, 14640-.
11
Caplan, M. R. (2000). . Biomacromolecules, 1, 627-.
12
Lopez de la Paz, M. (2002). . Proc. Natl. Acad. Sci, 99, 16052-.
13
Porat, Y. (2004). . Biochemistry, 43, 14454-.
14
Gazit, E.. (2002). . FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, 16, 77-.
15
Azriel, R. (2001). . J. Biol. Chem, 276, 34156-.
16
McGaughey, G. B.. (1998). . J. Biol. Chem, 273, 15458-.
17
Jang, H.-S. (2014). . Nature Commun, 5, 3665-.
18
Zhao, R. (2017). . Mol. Phys, 2017, 1400697-.
19
Zhao, J.-H. (2010). . Mol. Simul, 36, 1013-.
20
Sievers, S. A. (2011). . Nature, 475, 96-.
21
Do, T. D. (2013). . J. Phys. Chem. B, 117, 8436-.
22
Zhao, J.-H. (2013). . J. Mol. Model., 19, 151-.
23
Lin, Y.-F. (2011). . J. Taiwan Inst. Chem. Eng., 42, 394-.
24
Seo, J.-H. (2017). . Int. J. Mass Spec, 415, 55-.
25
Seo, J.-H. (2018). . Chem. Phys. Lett, 708, 61-.
26
Azriel, R. (2001). . J. Biol. Chem, 276, 34156-.
27
Porat, Y. (2004). . Biochem, 43, 14454-.
28
Porat, Y. (2003). . Biopolymers, 69, 161-.
- Submission Date
- 2018-12-17
- Revised Date
- 2019-01-19
- Accepted Date
- 2019-01-22
Other articles from this issue
- Amphetamine-type Stimulants in Drug Testing
- Comparison of Lipid Profiles in Head and Brain Samples of Drosophila Melanogaster Using Electrospray Ionization Mass Spectrometry (ESI-MS)
- Simultaneous Quantitative Determination of Nine Hallucinogenic NBOMe Derivatives in Human Plasma Using Liquid Chromatography Tandem Mass Spectrometry
- Study of CO 2 + (CO 2 ) n Cluster in a Paul Ion Trap
- Oligomer Complexes of the (VQIVYK + NNQQNY) and (VQIVYK + LYQLEN) Mixing Solutions
- Development and Validation of an LC-MS/MS Method for Determination of Damaurone D in Rat Plasma and its Application to Pharmacokinetic Study in Rats
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.